T cell dysfunction and metabolic disruption in chronic hepatitis C virus infection
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By
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Bhavya Sajeet
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Uma Ganapathi
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Kiruthika Naganathan
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Aarthi Parthasarathy
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Pramod Darvin
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Varun Sasidharan Nair
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June 1, 2026
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Objective:
To summarize the mechanisms of T cell dysfunction, epigenetic programming, and metabolic disruption in chronic hepatitis C virus (HCV) infection.
Key Findings:
- Chronic HCV infection leads to T cell exhaustion characterized by reduced proliferation and impaired cytokine production.
- Intrahepatic accumulation of regulatory T cells suppresses antiviral immune responses.
- Chronic HCV infection induces significant metabolic dysfunction, including oxidative stress and altered glycolytic adaptation.
Interpretation:
Remove unsupported conclusions and rephrase to reflect only the source material.
Limitations:
- Ensure limitations are directly sourced from the material.
Conclusion:
Revise to eliminate unsupported implications and focus on summarizing the findings.
