Tranexamic Acid in Lower Extremity Endoprosthetic Reconstruction for Oncologic Indications: A Retrospective Comparative Study of 617 Patients - Summary - MDSpire
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Use of Tranexamic Acid in Oncologic Lower Limb Endoprosthetic Reconstruction: A Retrospective Analysis of 617 Cases

  • By

  • Stephen W. Chenard

  • Akhil Rekulapelli

  • Riley S. Gilbertson

  • Connor S. Charton

  • William F. Hefley

  • Michael J. Colello

  • Jennifer L. Halpern

  • Herbert S. Schwartz

  • Daniel J. Johnson

  • Jonathan G. Schoenecker

  • Joshua M. Lawrenz

  • June 1, 2026

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Objective:

To evaluate the association between perioperative TXA administration, blood loss, and thromboembolic complications in patients undergoing lower extremity endoprosthetic reconstruction for oncologic indications.

Approach:
  • Data Collection: Demographic, surgical, and outcome variables were extracted from electronic health records.
Key Findings:
  • TXA was administered to 166 patients, with various routes of administration including oral and intravenous.
  • No significant differences in baseline characteristics or major preoperative medical comorbidities between TXA-treated and non-TXA-treated groups.
  • A higher proportion of TXA-treated patients were on direct factor Xa inhibitors and fewer on vitamin K antagonists.
Interpretation:

Limitations:
  • Retrospective design may introduce selection bias.
  • Potential confounding factors not fully controlled for.
Conclusion:

The findings contribute to understanding the role of TXA in reducing blood loss in oncologic surgeries.

Original Source(s)

Tranexamic Acid in Lower Extremity Endoprosthetic Reconstruction for Oncologic Indications: A Retrospective Comparative Study of 617 Patients

  • by Stephen W. Chenard, Akhil Rekulapelli, Riley S. Gilbertson, Connor S. Charton, William F. Hefley, Michael J. Colello, Jennifer L. Halpern, Herbert S. Schwartz, Daniel J. Johnson, Jonathan G. Schoenecker, Joshua M. Lawrenz

  • June 1, 2026

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