Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan - Summary - MDSpire

Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan

  • By

  • Tetsuya Takikawa

  • Yoichi Kakuta

  • Kazuhiro Kikuta

  • Serina Haruyama

  • Ami Kawamoto

  • Shinichiro Shinzaki

  • Katsuyoshi Matsuoka

  • Hiroshi Nagai

  • Takanori Sano

  • Mikihiro Fujiya

  • Takuto Saiki

  • Masanao Nakamura

  • Atsushi Nishida

  • Sakiko Hiraoka

  • Takayuki Matsumoto

  • Katsuya Endo

  • Kazuyuki Narimatsu

  • Shojiro Yamamoto

  • Takashi Kagaya

  • Shin-ichiro Hagiwara

  • Noritaka Takatsu

  • Hiroshi Nakase

  • Kazuichi Okazaki

  • Yoki Furuta

  • Tetsu Kinjo

  • Soichiro Ishihara

  • Hirotake Sakuraba

  • Takashi Tashiro

  • Makoto Naganuma

  • Fukunori Kinjo

  • Tomohisa Takagi

  • Tadakazu Hisamatsu

  • Mitsuhiro Kawano

  • Atsushi Masamune

  • June 29, 2026

  • 0 min

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Objective:

To clarify the association between acute pancreatitis (AP) and inflammatory bowel disease (IBD) in Japan, focusing on clinical characteristics and differences between ulcerative colitis (UC) and Crohn's disease (CD).

Approach:
  • Study Design: A descriptive retrospective study was conducted at 28 institutions in Japan, collecting cumulative AP events after IBD diagnosis.
  • Data Collection: Data on IBD and AP-related variables were extracted from electronic medical records, including demographics, disease characteristics, and AP severity.
  • Statistical Analyses: Continuous variables were analyzed using means or medians, while categorical variables were assessed with Chi-square or Fisher’s exact tests. Logistic regression analyses were performed to identify factors associated with severe AP.
Key Findings:
  • AP occurs more frequently in IBD patients than in the general population, with an odds ratio of 3.11 (95% CI, 2.93–3.30).
  • Drug-induced AP is a common etiology in IBD-associated AP.
  • Duodenal involvement and type 2 autoimmune pancreatitis are recognized as risk factors for AP in IBD patients.
  • AP in IBD patients may be less severe compared to AP in the general population.
Interpretation:

The study presents unique clinical characteristics of AP in IBD patients, indicating differences in etiology and severity compared to the general population.

Limitations:
  • The study is retrospective and may be subject to biases inherent in such designs.
  • Data collection was limited to electronic medical records, which may not capture all relevant clinical information.
Conclusion:

This nationwide study provides insights into the characteristics of AP in IBD patients in Japan.

Original Source(s)

Clinical characteristics of acute pancreatitis in patients with inflammatory bowel disease: a nationwide survey in Japan

  • by Tetsuya Takikawa, Yoichi Kakuta, Kazuhiro Kikuta, Serina Haruyama, Ami Kawamoto, Shinichiro Shinzaki, Katsuyoshi Matsuoka, Hiroshi Nagai, Takanori Sano, Mikihiro Fujiya, Takuto Saiki, Masanao Nakamura, Atsushi Nishida, Sakiko Hiraoka, Takayuki Matsumoto, Katsuya Endo, Kazuyuki Narimatsu, Shojiro Yamamoto, Takashi Kagaya, Shin-ichiro Hagiwara, Noritaka Takatsu, Hiroshi Nakase, Kazuichi Okazaki, Yoki Furuta, Tetsu Kinjo, Soichiro Ishihara, Hirotake Sakuraba, Takashi Tashiro, Makoto Naganuma, Fukunori Kinjo, Tomohisa Takagi, Tadakazu Hisamatsu, Mitsuhiro Kawano, Atsushi Masamune

  • June 29, 2026

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