Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study - Summary - MDSpire

Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study

  • By

  • Chantal F Ski

  • Catriona S Jennings

  • Dirk De Bacquer

  • Kornelia Kotseva

  • John William McEvoy

  • Guy De Backer

  • Iris Erlund

  • Sandra Ganly

  • Terhi Vihervaara

  • Gregory Yoke Hong Lip

  • Kausik K Ray

  • Lars Rydén

  • Agnieszka Adamska

  • Ana Abreu

  • Wael Almahmeed

  • Ade Meidian Ambari

  • Junbo Ge

  • Hosam Hasan-Ali

  • Yong Huo

  • Piotr Jankowski

  • Rodney M Jimenez

  • Yong Li

  • Ahmad Syadi Mahmood Zuhdi

  • Abel Makubi

  • Amam Chinyere Mbakwem

  • Lilian Mbau

  • Jose Luis Navarro Estrada

  • Okechukwu Samuel Ogah

  • Elijah Nyainda Ogola

  • Adalberto Quintero-Baiz

  • Mahmoud Umar Sani

  • Maria Ines Sosa Liprandi

  • Jack Wei Chieh Tan

  • Miguel Alberto Urina Triana

  • Tee Joo Yeo

  • David A Wood

  • David R Thompson

  • on behalf of the INTERASPIRE Investigators

  • November 13, 2025

  • 0 min

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Objective:

To examine the association between anxiety, depression, and achieving recommended cardiovascular prevention standards, specifically the INTERASPIRE-Guideline Target Score (GTS), in patients with coronary heart disease (CHD) across WHO regions.

Key Findings:
  • Higher prevalence of anxiety and depression symptoms in women compared to men (p < 0.05).
  • Increased severity of anxiety and depression symptoms correlates with poorer achievement of secondary prevention targets (p < 0.01).
  • Adjusted odds ratios indicate a significant association between anxiety/depression severity and suboptimal INTERASPIRE-GTS (p < 0.01).
Interpretation:

The findings suggest that patients with CHD exhibiting symptoms of anxiety and/or depression are less likely to meet guideline standards for secondary prevention, highlighting the critical need for integrated mental health management in treatment plans to improve cardiovascular outcomes.

Limitations:
  • Cross-sectional design limits causal inferences, making it difficult to establish direct relationships.
  • Data collected from specific regions may not be generalizable globally, potentially affecting the applicability of findings.
Conclusion:

Integrating mental health support in secondary prevention programs is essential to improve outcomes for patients with CHD, acknowledging the interplay between mental and cardiovascular health and advocating for holistic treatment approaches.

Original Source(s)

Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study

  • by Chantal F Ski, Catriona S Jennings, Dirk De Bacquer, Kornelia Kotseva, John William McEvoy, Guy De Backer, Iris Erlund, Sandra Ganly, Terhi Vihervaara, Gregory Yoke Hong Lip, Kausik K Ray, Lars Rydén, Agnieszka Adamska, Ana Abreu, Wael Almahmeed, Ade Meidian Ambari, Junbo Ge, Hosam Hasan-Ali, Yong Huo, Piotr Jankowski, Rodney M Jimenez, Yong Li, Ahmad Syadi Mahmood Zuhdi, Abel Makubi, Amam Chinyere Mbakwem, Lilian Mbau, Jose Luis Navarro Estrada, Okechukwu Samuel Ogah, Elijah Nyainda Ogola, Adalberto Quintero-Baiz, Mahmoud Umar Sani, Maria Ines Sosa Liprandi, Jack Wei Chieh Tan, Miguel Alberto Urina Triana, Tee Joo Yeo, David A Wood, David R Thompson, on behalf of the INTERASPIRE Investigators

  • November 13, 2025

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