Objective:

To investigate the occurrence and management of severe hemolytic anemia and acute kidney injury in a patient with hepatocellular carcinoma following hepatic arterial infusion chemotherapy with raltitrexed and oxaliplatin.

Approach:

Key Findings:

• The patient experienced severe hemolytic anemia and acute kidney injury suspected to be induced by oxaliplatin, with laboratory results indicating a substantial increase in hemolytic markers.
• Exchange transfusion was initiated based on clinical manifestations and laboratory findings, leading to satisfactory therapeutic outcomes.

Interpretation:

This case presents severe adverse reactions, such as hemolytic anemia and acute kidney injury, following oxaliplatin administration in a patient with hepatocellular carcinoma.

Limitations:

• This is a single case report, limiting generalizability to a broader patient population.

Conclusion:

This case highlights the need for awareness of oxaliplatin-related complications in hepatocellular carcinoma patients.

Sources:

• Affiliated Hospital of Qingdao University
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