Pancreatic Cancer Screening in New-onset and Deteriorating Diabetes: Preliminary Results From the PANDOME Study - Summary - MDSpire

Pancreatic Cancer Screening in New-onset and Deteriorating Diabetes: Preliminary Results From the PANDOME Study

  • By

  • Richard C Frank

  • Brian Shim

  • Tammy Lo

  • Deep Pandya

  • Thorsten L Krebs

  • Charles Ma

  • Daniel Labow

  • Jill Denowitz

  • Naveen Anand

  • Pramila Krumholtz

  • Kiyoe Sullivan

  • Mark Sanchez

  • Xiang Eric Dong

  • Ramanathan Seshadri

  • Antolin Trinidad

  • Dugho Jin

  • May 29, 2025

  • 0 min

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Objective:

To evaluate the feasibility and safety of screening for pancreatic cancer (PC) in individuals aged ≥50 years with new-onset diabetes (NOD) or deteriorating diabetes (DD), emphasizing the significance of early detection in high-risk populations.

Key Findings:
  • Detection rate of stage 1 pancreatic ductal adenocarcinoma was 0.9% (1/109), indicating a need for improved screening methods.
  • DD cohort had higher hemoglobin A1c levels, greater weight loss, and increased insulin requirements compared to NOD cohort, suggesting more severe disease.
  • Endocrinologists were the primary referral source for the DD cohort, underscoring their role in early detection.
Interpretation:

The study supports the inclusion of DD in pancreatic cancer screening, highlighting the role of endocrinologists in referrals and the need for tailored screening strategies.

Limitations:
  • Small sample size with only 109 participants, which may limit the generalizability of the findings.
  • Short follow-up period may limit long-term conclusions and the ability to assess the effectiveness of screening.
Conclusion:

The PANDOME trial indicates potential for early detection of pancreatic cancer in high-risk diabetes patients, warranting further research with larger cohorts and longer follow-up periods.

Original Source(s)

Pancreatic Cancer Screening in New-onset and Deteriorating Diabetes: Preliminary Results From the PANDOME Study

  • by Richard C Frank, Brian Shim, Tammy Lo, Deep Pandya, Thorsten L Krebs, Charles Ma, Daniel Labow, Jill Denowitz, Naveen Anand, Pramila Krumholtz, Kiyoe Sullivan, Mark Sanchez, Xiang Eric Dong, Ramanathan Seshadri, Antolin Trinidad, Dugho Jin

  • May 29, 2025

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