High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China - Summary - MDSpire
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High serum FSH levels on day 7 of stimulation are negatively associated with oocyte retrieval in GnRH antagonist protocols: real-world evidence from 9,969 IVF cycles in China
To investigate the relationship between serum FSH levels on Day 7 of ovarian stimulation specifically in GnRH antagonist protocols and the number of oocytes retrieved in IVF cycles.
Key Findings:
Lower serum FSH on Day 7 was associated with fewer oocytes collected (β = −0.531, 95% CI, p < 0.0001).
A serum FSH threshold of 9.13 mIU/mL was identified; above this level, each 1 mIU/mL increase reduced oocyte collection by 0.07 (95% CI).
Below 9.13 mIU/mL, each 1 mIU/mL increase was associated with an increase of 1.18 oocytes collected (95% CI).
Interpretation:
The findings suggest that serum FSH levels can guide adjustments in FSH dosing during ovarian stimulation, potentially optimizing oocyte retrieval outcomes.
Limitations:
Retrospective design may introduce biases, and potential confounding factors were not controlled for.
Findings are specific to GnRH antagonist protocols and may not generalize to other stimulation protocols.
Conclusion:
Optimizing FSH dosing based on serum levels could improve oocyte retrieval outcomes in IVF, warranting further prospective studies to validate these findings and explore specific dosing strategies.
