To characterize resting-state functional differences across clinically defined bothersome tinnitus (BT), non-bothersome tinnitus (NBT), and hospital-based non-tinnitus control groups, focusing on imaging differences related to tinnitus phenotype.
Approach:
Key Findings:
Significant group differences in functional connectivity between BT and NBT were observed, particularly in the left ACC/mOFC cluster.
Lower ReHo values were found in NBT compared to both BT and controls.
fALFF analyses indicated region-specific differences across multiple brain regions, with consistent differences between BT and NBT.
No significant correlations between FC and ReHo within the BT group were found, and no associations between imaging indices and clinical measures survived FDR correction.
Interpretation:
The findings suggest phenotype-related functional differences between BT and NBT, highlighting the need for further exploration of these imaging features.
Limitations:
The study's cross-sectional design limits causal inferences.
The sample size may restrict the generalizability of the findings to broader populations.
Conclusion:
The study reveals functional differences in resting-state measures between tinnitus phenotypes, indicating the need for further exploration of these imaging features.
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