To assess the applicability of liver stiffness measurement (LSM) in guiding conditioning regimen selection and its diagnostic accuracy for identifying Sinusoidal Obstructive Syndrome (SOS) after allogeneic HSCT.
Key Findings:
Baseline LSM did not predict SOS development, but increased significantly in patients who developed SOS post-transplant.
A cut-off LSM value of X kPa was determined for diagnosing SOS, aiding in differentiating it from other liver injuries.
Interpretation:
LSM can be a useful tool in modifying treatment protocols for high-risk patients and diagnosing SOS, although it has limitations in specificity that should be considered.
Limitations:
EBMT criteria for SOS diagnosis have low specificity, potentially leading to misdiagnosis.
Imaging findings may overlap with other liver disorders, complicating diagnosis.
Conclusion:
LSM shows promise in guiding treatment and diagnosing SOS after HSCT, but further validation is needed to enhance its clinical utility.
