S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction - Summary - MDSpire
Advertisement
S-GRAS score and the complementary prognostic value of neutrophil-to-lymphocyte ratio in adrenocortical carcinoma: evidence for a synergistic interaction
To assess the prognostic values of the S-GRAS model and inflammation-based scores (NLR and PLR) in adrenocortical carcinoma, clarifying their potential interaction and complementary roles.
Key Findings:
The S-GRAS score demonstrated a C-index of 0.765, indicating superior discriminative ability compared to its individual components.
NLR was identified as a significant predictor of mortality (HR = 3.1; p=0.008), while PLR did not reach statistical significance.
A significant synergistic interaction between S-GRAS and NLR was found (HR = 1.177, p=0.009).
The combined use of S-GRAS and NLR provided superior prognostic discrimination (C-index=0.822) compared to their individual use.
Interpretation:
NLR offers independent and complementary predictive value to the S-GRAS score, with their combination enhancing prognostic discrimination, particularly in high-risk patient groups, suggesting a need for integrated assessment in clinical practice.
Limitations:
The study is retrospective and conducted at a single centre, which may limit generalizability.
The cohort partially overlaps with previous studies, potentially introducing bias in the findings.
Conclusion:
The combination of S-GRAS and NLR enhances prognostic assessment in adrenocortical carcinoma, with external validation confirming the robustness of the S-GRAS score, emphasizing its clinical relevance.
by Erik Bényei, Gergely Huszty, András Laki, Zsuzsanna Jakab, Gergely Kiss, Attila Kristóf Kovács, Katalin Borka, Andrea Uhlyarik, Katalin Eitler, Peter Igaz, Judit Tőke, Miklós Tóth
