To present a rare case of gallbladder mixed adenoneuroendocrine carcinoma (GB-MANEC) and review the literature on its clinicopathological management.
Approach:
Case Presentation: A 51-year-old female with abdominal complaints and anemia underwent imaging, which revealed an irregular mass in the gallbladder, and surgery, leading to the diagnosis of GB-MANEC.
Surgical Intervention: Radical surgery including cholecystectomy and partial liver resection was performed, with postoperative histopathology confirming GB-MANEC.
Adjuvant Therapy: Postoperative treatment included chemotherapy with cisplatin, gemcitabine, etoposide, and trastuzumab targeting HER2.
Key Findings:
GB-MANEC is a rare and aggressive tumor with a poor prognosis.
Histopathological diagnosis is crucial and confirmed through immunohistochemistry.
The patient remained free of recurrence during 7 months of follow-up.
Interpretation:
The case highlights the challenges in diagnosing and managing GB-MANEC.
Limitations:
The rarity of GB-MANEC limits the establishment of standardized treatment guidelines.
Current management strategies are largely extrapolated from other tumor types.
Conclusion:
Surgical treatment is the cornerstone of potentially curative management for GB-MANEC, with the role of adjuvant chemotherapy remaining undefined.
