Objective:

To compare the sealing efficacy and safety of three left atrial appendage (LAA) occluders—WATCHMAN, LAmbre, and LACBES—in a one-stop procedure combining catheter ablation (CA) and LAA occlusion (LAAO) for atrial fibrillation (AF).

Key Findings:

• PDL rates were 8.2% for WATCHMAN, 6.9% for LAmbre, and 4.1% for LACBES, with no statistically significant intergroup differences.
• Device type was not an independent predictor of PDL after adjusting for clinical risk profiles.
• Higher CHA₂DS₂-VASc score was an independent risk factor for PDL, while older age was a protective factor.
• No significant differences in device-related thrombus (DRT) or stroke incidence among the devices during follow-up.

Interpretation:

The WATCHMAN, LAmbre, and LACBES occluders demonstrated comparable effectiveness in achieving LAA closure in the one-stop AF procedure.

Limitations:

• Low event counts limited the statistical power for safety endpoints.
• The sample size was small, necessitating larger studies for confirmation of long-term safety comparisons.

Conclusion:

A high CHA₂DS₂-VASc score and younger age may be risk factors for PDL, warranting closer monitoring in these patient subgroups.