The interrelationships among insomnia, frailty, anxiety, and cognitive function in middle-aged and older adults: a cross-sectional study - Summary - MDSpire
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The interrelationships among insomnia, frailty, anxiety, and cognitive function in middle-aged and older adults: a cross-sectional study
To examine the relationships among insomnia, anxiety, frailty, and cognitive function in middle-aged and older adults, and to test whether frailty moderates the mediating role of anxiety between insomnia and cognition.
Key Findings:
Pre-frailty significantly moderated the insomnia–anxiety relationship (PSQI × Pre-frailty: β = 1.029, p = 0.017).
The indirect effect of insomnia on cognition through anxiety was significant in both robust (β = −0.053, 95% CI [−0.111, −0.004]) and pre-frail individuals (β = −0.090, 95% CI [−0.179, −0.007]).
The anxiety-mediated pathway was stronger in pre-frail individuals (Index = −0.037, 95% CI [−0.101, −0.0003]).
Both frailty (β = −1.3, p < 0.001) and insomnia severity (β = −0.176, p < 0.001) independently predicted cognitive function.
