To investigate the association between maternal chronic conditions and the risk of severe neonatal morbidity or mortality (SNM-M) in newborns.
Key Findings:
Newborns of mothers with multiple chronic conditions face higher risks of SNM-M.
Adjusted relative risk of SNM-M increases with the number of maternal conditions: 1.26 for one, 1.58 for two, and 2.01 for three or more.
Newborns of mothers with complex conditions (three or more affecting at least three body systems) had nearly double the risk of SNM-M.
Cardiometabolic conditions significantly elevate the risk, especially when maternal conditions require hospitalization.
Interpretation:
The study emphasizes the importance of maternal health history in predicting neonatal outcomes, suggesting that chronic conditions can adversely affect newborn health through various mechanisms.
Limitations:
Reliance on administrative diagnostic codes may limit accuracy.
Absence of laboratory severity markers.
Conclusion:
Integrating maternal chronic disease history into prenatal assessments can enhance neonatal risk stratification and improve outcomes.
