To explore transfer-level factors associated with clinical pregnancy after intracytoplasmic sperm injection (ICSI), emphasizing the exploratory nature of the study.
Key Findings:
Clinical pregnancy occurred in 37 of 300 transfers (12.3%).
Older maternal age was associated with lower odds of clinical pregnancy (aOR 0.91 per year, 95% CI 0.83–0.99).
Higher AMH levels were associated with higher odds of clinical pregnancy (aOR 2.02 per unit, 95% CI 1.39–2.94).
More invasive sperm-source categories were associated with lower odds of clinical pregnancy (aOR 0.39, 95% CI 0.17–0.92).
Blastocyst transfer was associated with higher odds of clinical pregnancy compared to cleavage-stage transfer (aOR 3.90, 95% CI 1.29–11.74).
Interpretation:
The findings suggest exploratory associations between female age, AMH, sperm source, and transfer stage with clinical pregnancy outcomes, but they are not sufficient for routine predictive implementation.
Calibration and coefficient stability remain uncertain.
Findings are hypothesis-generating and require larger external validation studies to confirm.
Conclusion:
The study highlights the importance of considering multiple transfer-day variables in clinical pregnancy outcomes but emphasizes the need for further research and validation.
