Efficacy and safety of phototherapy for jaundice in full-term newborns: a meta-analysis - Summary - MDSpire

Efficacy and safety of phototherapy for jaundice in full-term newborns: a meta-analysis

  • By

  • Xingzhen Feng

  • Zijun Liang

  • Huishi Ye

  • Shubin Xie

  • June 24, 2026

  • 0 min

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Objective:

To meta-analyze the efficacy and safety of phototherapy in treating full-term neonatal jaundice.

Approach:
  • Literature Search: Databases searched included PubMed, Embase, Cochrane Library, and Web of Science from January 1, 2000, to April 25, 2024, with no language restrictions.
Key Findings:
  • The meta-analysis included 647 full-term neonates from 14 studies.
  • The pooled mean reduction in serum total bilirubin (STB) was 5.43 mg/dL (95% CI: 5.30–5.56).
  • The STB reduction rate in all studies was greater than 18%.
  • Light-emitting diode phototherapy devices showed higher efficacy compared to fluorescent tube systems.
  • Phototherapy is safe with minimal adverse effects.
Interpretation:

Proper phototherapy significantly reduces STB levels in full-term neonates.

Limitations:
  • The analysis included only studies published in English.
  • Potential publication bias may affect the results.
Conclusion:

Phototherapy is an effective treatment for jaundice in full-term infants.

Original Source(s)

Efficacy and safety of phototherapy for jaundice in full-term newborns: a meta-analysis

  • by Xingzhen Feng, Zijun Liang, Huishi Ye, Shubin Xie

  • June 24, 2026

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