To analyze the molecular profile of adult patients with Scalp psoriasis (SP).
Approach:
Study Design: Cross-sectional analysis of inflammatory biomarkers in lesional scalp skin from SP patients and healthy controls using Olink high-throughput proteomics.
Cohorts: 20 SP patients and 12 healthy controls for proteomics; 11 SP patients and 5 healthy controls for ELISA.
Biomarker Assessment: 92 inflammatory biomarkers assessed; expression of Th2-type cytokines measured using ELISA.
Key Findings:
28 differentially expressed proteins (DEPs) identified in lesional SP compared to healthy controls (FC ≥ ±1.2, adjusted p-value <0.05).
SP exhibits a Th1/Th17/IL-12/IL-23-dominant molecular signature.
Down-regulation of Th2-type molecules (IL-4 and IL-5) in SP patients, with IL-4 showing a negative correlation with ss-IGA scores (r = −0.78, p < 0.01) and IL-5 with ss-IGA scores (r = −0.65, p < 0.05).
Interpretation:
Limitations:
Small sample size may limit generalizability.
Study focused only on lesional skin, not considering non-lesional areas.
Conclusion:
The proteomic profile provides insights into the immunological pathogenesis of scalp psoriasis.
