Functional magnetic resonance imaging (fMRI) as adjunct for planning laser interstitial thermal therapy (LITT) near eloquent structures - Summary - MDSpire

Functional magnetic resonance imaging (fMRI) as adjunct for planning laser interstitial thermal therapy (LITT) near eloquent structures

  • By

  • Ziad Rifi

  • Maya Harary

  • Patricia D. Walshaw

  • Andrew J. Frew

  • Richard G. Everson

  • Aria Fallah

  • Noriko Salamon

  • Won Kim

  • February 5, 2024

  • 0 min

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Objective:

To demonstrate the utility of fMRI in improving surgical outcomes, specifically in reducing postoperative deficits, of LITT in patients with intracranial lesions near eloquent structures.

Key Findings:
  • One patient did not undergo LITT due to significant eloquent involvement identified by fMRI, highlighting the importance of preoperative mapping.
  • fMRI effectively localized functional areas and indicated risks of postoperative deficits, demonstrating its critical role in surgical planning.
  • The technique improved surgical planning and intraoperative safety during LITT, suggesting a potential standard of care.
Interpretation:

fMRI serves as a valuable adjunct for preoperative mapping and intraoperative guidance, potentially reducing the risk of functional deficits in high-risk patients undergoing LITT, thereby enhancing overall surgical outcomes.

Limitations:
  • Retrospective design may introduce selection bias, affecting the reliability of outcomes.
  • Small sample size limits generalizability of findings, necessitating further studies.
  • Potential variability in fMRI protocols and interpretation could impact consistency in results.
Conclusion:

Incorporating fMRI into the planning of LITT for lesions near eloquent structures enhances surgical safety and may improve clinical outcomes.

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