From the Journals

Deep-UV Raman Reveals mRNA Encapsulation in Lipid Nanoparticles 

Spectroscopic analysis reveals lipid–RNA interactions governing nanoparticle formulation efficiency 

  • March 13, 2026

  • 2 min

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Researchers at the University at Albany unveiled a method utilizing deep-ultraviolet Raman spectroscopy to evaluate the encapsulation of messenger RNA (mRNA) within lipid nanoparticles (LNPs). This technique distinguishes between encapsulated and free mRNA, a crucial step for ensuring the stability and delivery efficacy of mRNA vaccines and therapeutics. By analyzing molecular vibrations, they established vibrational markers specific to lipid-mRNA interactions, helping to optimize formulations for safety and effectiveness in mRNA therapeutics.

Original Source(s)

Deep-UV Raman Reveals mRNA Encapsulation in Lipid Nanoparticles 

  • March 13, 2026

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