To characterize outcomes among infants undergoing hematopoietic cell transplantation (HCT) with a focus on those requiring critical care support during the first 100 days post-HCT.
Approach:
Study Design: A single center retrospective study including 107 infants who underwent HCT between 2003 and 2023.
Data Collection: Data was extracted from electronic medical records, focusing on demographics, clinical variables, transplant-related factors, and critical care admissions.
Key Findings:
41% of infants required critical care support (CC) within 100 days post-HCT, primarily for respiratory distress, with 56.8% requiring invasive mechanical ventilation (IMV).
Mortality risk was significantly higher for infants requiring CC (HR: 3.59).
Overall survival rates were 85.9% at 100 days and 73.5% at 1 year post-HCT.
Infants who underwent HCT after 2013 had a 59% lower risk of mortality compared to those transplanted before 2013.
Interpretation:
Limitations:
The study is retrospective and conducted at a single center, which may limit generalizability.
Limited data on predicting outcomes for infants requiring critical care support.
Conclusion:
Overall survival among infants undergoing HCT is high, with rates of 85.9% at 100 days and 73.5% at 1 year, even with elevated critical care admissions.
