Robotic-assisted bronchoscopy combined with digital tomosynthesis for pulmonary nodules characterization: a single center experience - Summary - MDSpire

Integration of Robotic Bronchoscopy and Digital Tomosynthesis for Characterizing Pulmonary Nodules: Insights from a Single-Center Study

  • By

  • Flavio Marco Mirabelli

  • Emma Repaci

  • Gian Piero Bandelli

  • Thomas Galasso

  • Martina Ferioli

  • Marco Ferrari

  • Filippo Natali

  • Tommaso Abbate

  • Teresa Calari

  • Stefania Damiani

  • Francesca Giunchi

  • Mattia Riefolo

  • Lorenzo Scrofani

  • Annalisa Altimari

  • Elisa Gruppioni

  • Daniela Di Luca

  • Federica Pasquali

  • Piero Candoli

  • July 21, 2026

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Objective:

To assess the diagnostic performance, safety, and clinical feasibility of integrating robotic-assisted bronchoscopy with digital tomosynthesis in evaluating peripheral pulmonary lesions.

Approach:
  • Study Design: Retrospective observational study conducted at a tertiary referral center, including 82 patients with 94 sampled pulmonary lesions.
  • Procedural Method: Utilized Ion™ robotic platform combined with LungVision system for augmented fluoroscopy during bronchoscopy.
  • Data Collection: Collected lesion features, procedural characteristics, diagnostic yield, and complications for statistical analysis.
Key Findings:
  • Definitive cyto-histologic diagnosis achieved in 74.5% of cases.
  • Lesions ≥10 mm had a 79.2% diagnostic rate compared to 59.1% for smaller nodules.
  • Upper lobe location and lesion visibility on CABT were significant predictors of diagnostic success.
Interpretation:

The integration of robotic-assisted bronchoscopy with the LungVision system demonstrated high diagnostic efficacy and a favorable safety profile for sampling peripheral lung lesions.

Limitations:
  • Follow-up data for non-diagnostic cases were unavailable, preventing assessment of false-negative rates and sensitivity.
  • Significant costs associated with the procedure warrant further validation in future studies.
Conclusion:

The study presents findings on the efficacy and safety of the combined approach for diagnosing peripheral pulmonary lesions, indicating the need for future prospective studies.

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