Bone health in asthma: a twofold effect of disease and pharmacotherapy
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By
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Sidian Yang
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Yihao Wang
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Xingchao Li
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Yewen Niu
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Liming Lei
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Zichao Han
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June 2, 2026
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Objective:
To elucidate the mechanisms by which asthma affects bone health and corresponding clinical management strategies.
Key Findings:
- Asthma involves persistent airway inflammation that can negatively impact bone health.
- Chronic inflammation and glucocorticoid therapy act as independent, additive risk factors for skeletal health.
- Children with asthma are particularly vulnerable to corticosteroid-related adverse effects on bone development.
Interpretation:
Limitations:
- The review lacks a systematic framework for the combined effects of asthma-related inflammation and glucocorticoid therapy on bone health.
Conclusion:
A two-hit model is proposed to understand the impact of asthma and its treatments on bone health.
