State of the art and future perspectives on the management of spheno-orbital meningiomas: a meta-analysis comparing transorbital and transcranial approaches - Summary - MDSpire
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State of the art and future perspectives on the management of spheno-orbital meningiomas: a meta-analysis comparing transorbital and transcranial approaches
To quantitatively evaluate existing studies comparing surgical outcomes of spheno-orbital meningiomas (SOMs) treated with endoscopic transorbital approaches (ETOA) versus standard transcranial techniques, highlighting the need for comparative evidence.
Key Findings:
Gross total resection (GTR) was lower with ETOA (21.1%) compared to transcranial approaches (48.0%), with statistical significance (p=0.047).
Interpretation:
ETOA shows superior proptosis improvement and comparable visual outcomes, but lower GTR rates, which may impact long-term tumor control. Complication rates did not significantly differ, suggesting ETOA is a valid option for selected cases.
Limitations:
Shorter follow-up duration in ETOA studies may influence recurrence and progression rates.
Heterogeneity in patient selection and outcome definitions complicates comparisons, and potential biases in study selection should be considered.
Conclusion:
ETOA represents a promising surgical strategy for SOMs, particularly for cases with predominant orbital involvement, while transcranial techniques remain essential for extensive intracranial control. Longer follow-up is necessary for assessing long-term tumor control and understanding the implications of lower GTR rates.
by Edoardo Porto, Giorgio Fiore, Arianna Barbotti, Giulio A Bertani, Massimiliano Del Bene, Giovanni Marfia, Francesco Corrivetti, Matteo de Notaris, Domenico Solari, Gustavo Pradilla, Hani J Marcus, Marco Locatelli, Francesco DiMeco
