Uric Acid Stone Dissolution Peaked at pH 7.2 - Summary - MDSpire
From the Journals

Uric Acid Stone Dissolution Peaked at pH 7.2

In vitro study found dissolution rates increased sharply above pH 6.5 and were tenfold higher after stone fragmentation.

  • By

  • Mouj Hijazi

  • May 12, 2026

  • 4 min

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A recent study in European Urology Open Science demonstrated that urine alkalinization to a pH of 7.0 to 7.2 significantly enhances uric acid stone dissolution. Researchers assessed the dissolution rates of uric acid stones in artificial urine, identifying that optimal dissolution occurs between pH 6.5 to 7.2, aligning with EAU guidelines. The study revealed that disintegrated stones dissolved at rates tenfold higher than intact stones. While higher urine pH poses concerns for calcium phosphate stone formation, potassium citrate may be preferable in minimizing this risk. Clinical validation is necessary.

Original Source(s)

Uric Acid Stone Dissolution Peaked at pH 7.2

  • by Mouj Hijazi

  • May 12, 2026

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