Bridging the Gap in Chronic Prurigo Care: Evidence-Based Diagnostic and Therapeutic Recommendations from a Delphi Consensus Panel - Summary - MDSpire

Bridging the Gap in Chronic Prurigo Care: Evidence-Based Diagnostic and Therapeutic Recommendations from a Delphi Consensus Panel

  • By

  • Pedro Mendes-Bastos

  • Inês Lobo

  • Gilberto Pires da Rosa

  • Rita Pimenta

  • Margarida Gonçalo

  • May 18, 2026

  • 0 min

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Objective:

To establish evidence-based recommendations for the diagnosis and management of chronic prurigo (CPG), particularly in light of recent therapeutic advances that necessitate updated guidelines.

Key Findings:
  • CPG treatment should be personalized based on disease severity and patient-reported outcomes, with systemic options including biologics approved for CPG and additional off-label therapies.
  • CPG is characterized by intense pruritus and scratch-associated skin lesions, with a complex pathophysiology involving immune and neural mechanisms.
Interpretation:

The findings emphasize the need for standardized, evidence-based guidelines to improve CPG management, addressing both the clinical and psychological aspects of the disease, such as the impact of chronic itch on mental health.

Limitations:
  • Limited prevalence data for CPG in the Portuguese population, which may affect the generalizability of the findings.
  • Potential underdiagnosis due to overlapping symptoms with other dermatological diseases, which could lead to inadequate treatment and poorer patient outcomes.
Conclusion:

The consensus recommendations aim to provide dermatologists and healthcare professionals with a structured approach to optimize CPG diagnosis and treatment, ultimately improving patient care.

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