Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel - Summary - MDSpire

Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel

  • By

  • Lubna Q. Khasawneh

  • Mais N. Alqasrawi

  • Zeina N. Al-Mahayri

  • Lilas Dabaghie

  • Sahar M. Altoum

  • Gohar Jamil

  • Salahdein Aburuz

  • Dana Hamza

  • Lizy George

  • Faiz Al-Bakshy

  • Kaes Al-Anee

  • Khuzama AlAhamad

  • Fatma Al-Maskari

  • Husam Ouda

  • Juma AlKaabi

  • George P. Patrinos

  • Bassam R. Ali

  • June 24, 2026

  • 0 min

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Objective:

To evaluate the role of ABCB1 and CYP2C19 variants on major adverse cardiovascular events (MACE) in patients with acute coronary syndrome (ACS) treated with clopidogrel.

Approach:
  • Study Design: Retrospective cohort study involving 174 patients with ACS treated with clopidogrel.
  • Genotyping: Performed using real-time PCR® TaqMan assays for ABCB1 and CYP2C19 variants.
  • Statistical Analysis: Associations with 1-year MACE were assessed using genotype, carrier status, and multivariable logistic regression.
Key Findings:
  • Minor allele frequencies for ABCB1 variants were 48.85% (rs1045642), 50% (rs2032582), and 51.44% (rs1128503).
  • No significant correlation between ABCB1 alleles and MACE outcomes (p-value > 0.05).
  • CYP2C19*2 showed a weak trend of increased risk of MACE (RR = 1.41; 95% CI: 0.95–2.10; p-value = 0.08).
  • CYP2C19*3 (1.15%) was not significantly related to any outcomes.
  • Only age showed a non-significant trend toward higher risk in multivariable analysis.
Interpretation:

The study found no significant link between common ABCB1 variants and MACE in clopidogrel-treated ACS patients from the UAE.

Limitations:
  • Retrospective design may limit causal inferences.
  • Sample size may not be sufficient to detect small effect sizes.
  • Findings may not be generalizable beyond the UAE population.
Conclusion:

The study did not find significant predictors of MACE outcomes from ABCB1 variants in the studied population.

Original Source(s)

Association of ABCB1 and CYP2C19 polymorphisms with major adverse cardiovascular complications in patients taking clopidogrel

  • by Lubna Q. Khasawneh, Mais N. Alqasrawi, Zeina N. Al-Mahayri, Lilas Dabaghie, Sahar M. Altoum, Gohar Jamil, Salahdein Aburuz, Dana Hamza, Lizy George, Faiz Al-Bakshy, Kaes Al-Anee, Khuzama AlAhamad, Fatma Al-Maskari, Husam Ouda, Juma AlKaabi, George P. Patrinos, Bassam R. Ali

  • June 24, 2026

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