Successful outcomes of pediatric dacryocystorhinostomy with adjunctive 5-fluorouracil - Summary - MDSpire

Positive Results of Pediatric Dacryocystorhinostomy Enhanced by Intraoperative 5-Fluorouracil

  • By

  • Alina K. Sinha

  • Ethan L. Kahana

  • Tomas E. Meijome

  • Adam Jacobson

  • Jane Z. Spadaro

  • Stella Y. Chung

  • Alon Kahana

  • July 17, 2026

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Objective:

To determine whether nasal intramucosal 5-fluorouracil (5-FU) injection improves outcomes after external dacryocystorhinostomy (DCR) in pediatric patients with nasolacrimal duct obstruction (NLDO).

Approach:
  • Study Design: Multi-center retrospective non-comparative case series review of DCR cases with intra-operative 5-FU injection performed between 2014 and 2023 on patients aged < 18 years.
  • Patient Review: Each case was reviewed for epiphora recurrence following surgery with 5-FU injection.
Key Findings:
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Interpretation:

Adjuvant intramucosal 5-FU demonstrated a 100% success rate of epiphora not recurring following pediatric DCR without complications.

Limitations:
  • Small sample size.
  • Retrospective study design.
Conclusion:

Intraoperative 5-FU may enhance the success of DCR in pediatric patients, particularly those at higher risk of recurrence.

Original Source(s)

Successful outcomes of pediatric dacryocystorhinostomy with adjunctive 5-fluorouracil

  • by Alina K. Sinha, Ethan L. Kahana, Tomas E. Meijome, Adam Jacobson, Jane Z. Spadaro, Stella Y. Chung, Alon Kahana

  • July 17, 2026

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