Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project - Summary - MDSpire

Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project

  • By

  • M. J. Scheltema

  • K. J. Tay

  • A. W. Postema

  • D. M. de Bruin

  • J. Feller

  • J. J. Futterer

  • A. K. George

  • R. T. Gupta

  • F. Kahmann

  • C. Kastner

  • M. P. Laguna

  • S. Natarajan

  • S. Rais-Bahrami

  • A. R. Rastinehad

  • T. M. de Reijke

  • G. Salomon

  • N. Stone

  • R. van Velthoven

  • R. Villani

  • A. Villers

  • J. Walz

  • T. J. Polascik

  • J. J. M. C. H. de la Rosette

  • September 16, 2016

  • 0 min

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Objective:

To define the use of multiparametric MRI (mpMRI) and MR-targeted biopsies in clinical practice and focal therapy for prostate cancer (PCa), emphasizing its significance in improving patient outcomes.

Key Findings:
  • mpMRI shows high positive predictive values (PPV) for detecting clinically significant PCa, with PPV of 98% in the peripheral zone, indicating its reliability.
  • The negative predictive value (NPV) of mpMRI ranges from 63% to 98% across studies, highlighting variability in diagnostic accuracy.
  • mpMRI-TRUS fusion targeted biopsies improve detection rates of clinically significant PCa compared to traditional TRUS-guided biopsies, suggesting a shift in biopsy techniques.
  • Expert consensus recommends repeated mpMRI during surveillance after focal therapy, underlining its importance in ongoing patient management.
Interpretation:

The findings suggest that mpMRI is a valuable tool in the detection and management of clinically significant PCa, although results may vary based on the quality of imaging and expertise, which should be considered in clinical applications.

Limitations:
  • Results may not reflect general urological practice due to the high standards of expert centers, which may not be achievable in all settings.
  • The consensus process may be influenced by the selection of participating experts, potentially introducing bias.
Conclusion:

mpMRI and MR-targeted biopsies are essential in the clinical management of PCa, warranting further evaluation of their role in standard diagnostics to enhance patient care.

Original Source(s)

Utilization of multiparametric prostate magnetic resonance imaging in clinical practice and focal therapy: report from a Delphi consensus project

  • by M. J. Scheltema, K. J. Tay, A. W. Postema, D. M. de Bruin, J. Feller, J. J. Futterer, A. K. George, R. T. Gupta, F. Kahmann, C. Kastner, M. P. Laguna, S. Natarajan, S. Rais-Bahrami, A. R. Rastinehad, T. M. de Reijke, G. Salomon, N. Stone, R. van Velthoven, R. Villani, A. Villers, J. Walz, T. J. Polascik, J. J. M. C. H. de la Rosette

  • September 16, 2016

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