Chronological age was not independently associated with ultra-early safety or arrhythmic outcomes after contemporary atrial fibrillation ablation: a real-world single-center study - Summary - MDSpire
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Chronological age was not independently associated with ultra-early safety or arrhythmic outcomes after contemporary atrial fibrillation ablation: a real-world single-center study
To assess the association between age and early procedural safety and ultra-early arrhythmic outcomes following AF ablation in an unselected real-world cohort.
Approach:
Study Design: Retrospective analysis of 217 consecutive patients who underwent transcatheter ablation for atrial fibrillation between January 2022 and December 2023.
Age Analysis: Age was analyzed using three predefined cutoffs (< 65, < 70, < 80 years) and as a continuous variable.
Endpoints: Primary safety endpoint: composite of pericardial effusion, periprocedural bleeding, stroke or TIA, acute coronary events, cardiovascular or procedure-related death. Secondary endpoint: composite of AF recurrence and persistence within 48 hours.
Statistical Analysis: Multivariable logistic regression analyses were performed to assess the independent association between age and outcomes.
Key Findings:
No significant differences in early complications or arrhythmic outcomes across age cutoffs.
Age was not independently associated with procedural safety (OR 0.99; 95% CI 0.93–1.06; p = 0.812), AF recurrence (OR 1.01; 95% CI 0.97–1.05; p = 0.77), or AF persistence (OR 1.00; 95% CI 0.96–1.05; p = 0.91).
Interpretation:
Age alone may not be a major determinant of ultra-early procedural outcomes in appropriately selected patients undergoing AF ablation.
Limitations:
Single-center study may limit generalizability.
Retrospective design may introduce selection bias.
Conclusion:
Age was not independently associated with procedural safety or ultra-early arrhythmic outcomes following AF ablation.
by Gennaro De Rosa, Marco Giuggia, Mattia Peyracchia, Martina Peddis, Roberto Di Summa, Elisa Pelissero, Giuseppe Trapani, Fabio Ugliano, Francesco Fiore, Giuseppe Corazzelli, Plinio Cirillo, Gaetano Senatore
