Objective:

To evaluate the association between the Inflammatory Burden Index (IBI) and 1-year major adverse cardiovascular events (MACE) in patients with heart failure with preserved ejection fraction (HFpEF) following myocardial infarction (MI).

Approach:

Key Findings:

• 74 patients (12.5%) experienced MACE during the 1-year follow-up.
• Higher logIBI was independently associated with increased risk of 1-year MACE (HR 1.828, 95% CI 1.529–2.186, P < 0.001).
• In a sensitivity model, high IBI was also associated with increased MACE risk (HR 4.126, 95% CI 2.512–6.776, P < 0.001).
• Adding logIBI improved the 365-day AUC from 0.790 to 0.832 and increased the C-index from 0.776 to 0.817.

Interpretation:

In patients with HFpEF and documented MI, higher logIBI is associated with an increased risk of 1-year MACE and enhances risk discrimination when added to a clinical model.

Limitations:

• The study is limited by its retrospective design and single-center nature.
• The final analytic dataset did not include baseline records for 33 patients lost to follow-up, preventing formal comparison.

Conclusion:

Higher logIBI is associated with 1-year MACE in HFpEF patients post-MI and may serve as a practical measure of inflammatory burden, though further validation is required.

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This content is an AI-generated, fully rewritten summary based on a published scholarly article. It does not reproduce the original text and is not a substitute for the original publication. Readers are encouraged to consult the source for full context, data, and methodology.