Integrated multi-omics profiling of the early post-infarct heart reveals a hub gene network associated with myeloid-driven inflammation - Summary - MDSpire

Integrated multi-omics profiling of the early post-infarct heart reveals a hub gene network associated with myeloid-driven inflammation

  • By

  • Zeyang Wang

  • Jinhu Shi

  • Yinchuan Lai

  • Song Wang

  • July 13, 2026

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Objective:

To define the key transcriptional programs and immune dynamics during the early inflammatory phase (EIP) of acute myocardial infarction (AMI).

Approach:
  • Data Integration: Performed an integrated analysis of time-series bulk RNA-sequencing datasets and single-cell RNA-seq data from cardiac immune cells.
  • Analysis Techniques: Applied inflammatory progression scoring and weighted gene co-expression network analysis (WGCNA) to identify critical gene modules and hub genes.
  • Validation: Validated gene expression in an external dataset, a murine AMI model, and a human peripheral blood cohort.
Key Findings:
  • Identified 160 dynamically regulated genes post-AMI, enriched in myeloid leukocyte activation and extracellular matrix organization.
  • Revealed a remodeled immune landscape at day 3 post-AMI with increased macrophages, monocytes, and neutrophils.
  • Distilled a core set of seven inflammation-associated hub genes (Grn, Igf1, Il18, Itgb2, Ncf2, Ncf4, Spp1) linked to myeloid cell infiltration.
Interpretation:

Limitations:
  • Exploratory single-gene ROC analyses in a human cohort had a very limited sample size, preventing reliable multi-gene model construction.
Conclusion:

Original Source(s)

Integrated multi-omics profiling of the early post-infarct heart reveals a hub gene network associated with myeloid-driven inflammation

  • by Zeyang Wang, Jinhu Shi, Yinchuan Lai, Song Wang

  • July 13, 2026

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