Stress Hyperglycemia Ratio and the Risk of Sepsis in Patients With Heart Failure: Retrospective Cohort Study From Medical Information Mart for Intensive Care-IV - Summary - MDSpire

Stress Hyperglycemia Ratio and the Risk of Sepsis in Patients With Heart Failure: Retrospective Cohort Study From Medical Information Mart for Intensive Care-IV

  • By

  • Xianzhen Cai

  • Baoxin Yan

  • Jinhao Chen

  • Junjun Ye

  • Jiating Su

  • Shuangshuang Tong

  • Bin Xie

  • Bingna Zhang

  • Jilin Li

  • April 17, 2026

  • 0 min

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Objective:

To investigate the association of stress hyperglycemia ratio (SHR) with the risk of sepsis among critically ill heart failure (HF) patients and explore the role of inflammation as a potential mediator in this relationship.

Key Findings:
  • Higher SHR levels were associated with an increased risk of sepsis in HF patients, indicating a potential area for clinical intervention.
  • Inflammation markers may mediate the relationship between SHR and sepsis occurrence, suggesting a complex interplay that warrants further investigation.
Interpretation:

The findings suggest that managing stress hyperglycemia could be crucial in reducing sepsis risk among heart failure patients, highlighting the importance of monitoring glycemic levels in critical care settings.

Limitations:
  • Retrospective design may introduce selection bias, potentially affecting the reliability of the findings.
  • Data limited to a single institution may affect generalizability to broader populations.
  • Potential confounding factors not fully accounted for could influence the observed associations.
Conclusion:

This study underscores the significance of SHR as a potential risk factor for sepsis in heart failure patients, highlighting the need for further investigation into its clinical implications and management strategies.

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