To assess whether bilateral distal femoral metadiaphyseal sclerosis represents a recognizable, reproducible imaging pattern and to examine its clinical, imaging, and histopathologic features.
Approach:
Study design: Retrospective, two-institution study in Belgium, comprising a descriptive patient cohort and a prevalence assessment using consecutive full-length lower-limb EOS radiographs obtained at one institution from 2021 to 2023.
Case assessment: Reviewed knee radiographs and available CT and MRI for lesion location, morphology, density, and signal; collected clinical and laboratory data and compared these with 30 age- and sex-matched controls.
Tissue correlation: Histopathologic evaluation was available for one patient.
Key Findings:
The described pattern consists of bilateral, round or elongated sclerotic lesions in the distal femoral metadiaphyses, without cortical erosion, periosteal reaction, or soft-tissue extension.
The study context reports that the pattern was observed in older women and that tissue evaluation in one patient provided correlation with fat necrosis and dystrophic calcification.
The supplied context does not provide cohort size, prevalence estimates, detailed imaging results, or comparative clinical and laboratory findings.
Interpretation:
The authors hypothesized that this presentation is a recognizable imaging pattern rather than an unusual manifestation of an established disorder. The provided context describes the study design and one histopathologic correlation but does not include enough results to assess the hypothesis further.
Limitations:
Retrospective study conducted at two institutions.
Histopathologic evaluation was available for only one patient.
The supplied article context ends before the full methods and results, limiting assessment of prevalence and comparative findings.
