Minimally invasive vs. open hepatectomy in patients with obesity and liver tumors: a systematic review and meta-analysis - Summary - MDSpire

Minimally invasive vs. open hepatectomy in patients with obesity and liver tumors: a systematic review and meta-analysis

  • By

  • Song Jiang

  • Wanjuan Li

  • Hongwei He

  • Yongchuan Huang

  • Wensong Liu

  • Qi Zheng

  • April 15, 2026

  • 0 min

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Objective:

To compare the surgical outcomes of minimally invasive hepatectomy (MIH) with open hepatectomy (OH) in obese patients with liver tumors.

Approach:
    Key Findings:
    • MIH was associated with a shorter operative time (WMD = -54.50, P = 0.01).
    • MIH resulted in reduced blood loss (WMD = -416.80, P < 0.00001) and a lower blood transfusion rate (OR = 0.31, P < 0.00001).
    • MIH had lower rates of overall complications (OR = 0.60, P < 0.0001) and major complications (OR = 0.61, P = 0.01).
    • MIH showed lower rates of biliary leakage (OR = 0.48, P = 0.02) and liver failure (OR = 0.26, P = 0.04).
    • Patients undergoing MIH had a shorter postoperative hospital stay (WMD = -7.21, P < 0.00001) and smaller tumor size (WMD = -1.06, P = 0.001).
    • No significant difference in mortality was observed between MIH and OH groups (OR = 0.68, P = 0.07).
    Interpretation:

    MIH appears to be a safe and effective treatment option for obese patients with liver tumors, offering several advantages over OH, particularly in terms of postoperative recovery and complication rates.

    Limitations:
    • The analysis included only studies that met specific inclusion criteria, which may limit generalizability.
    • Variability in surgical techniques and definitions of complications across studies may affect outcomes.
    Conclusion:

    MIH is associated with improved surgical outcomes compared to OH in obese patients with liver tumors, although mortality rates are similar between the two approaches.

    Sources:

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