To investigate the impact of genetic risk scores for Alzheimer's disease (AD-GRS) and coronary artery disease (CAD-GRS) on cognition in the FINGER randomized controlled trial, highlighting the relevance of these scores in understanding cognitive decline.
Key Findings:
Higher-risk individuals (AD-GRS and CAD-GRS above median) showed greater cognitive improvement than lower-risk individuals, suggesting that those with higher genetic risk can still benefit significantly from lifestyle changes.
AD-GRS and CAD-GRS were not significantly related to the overall intervention effect (P > 0.46), indicating that lifestyle interventions may be effective regardless of genetic predisposition.
Gender differences were observed in the impact of AD-GRS on cognitive outcomes, with higher-risk females showing more pronounced benefits from the intervention.
Interpretation:
Individuals with genetic susceptibility for Alzheimer's disease or coronary artery disease can benefit from multidomain lifestyle interventions, with notable gender differences in outcomes related to AD-GRS, suggesting tailored approaches may enhance intervention effectiveness.
Limitations:
Exploratory findings need verification across multiple trials for statistical power, as the current study's results may not be robust.
The study population may not represent genetically diverse populations, limiting the applicability of the findings to broader demographics.
Conclusion:
Multidomain lifestyle interventions can provide cognitive benefits regardless of genetic risk, emphasizing the importance of lifestyle changes in dementia prevention and suggesting that such interventions should be considered for all individuals at risk.
by Gazi Saadmaan, Maria Carolina Dalmasso, Maleeha Maria, Jenni Lehtisalo, Mikko Hiltunen, Minna U Kaikkonen, Esko Levälahti, Francesca Mangialasche, Markus Perola, Alfredo Ramirez, Ruth Stephen, Tiia Ngandu, Miia Kivipelto, Alina Solomon
