To synthesize evidence on how mechanical stimuli modulate neuroinflammation-driven spinal sensitization and propose a clearer mechanobiological framework for non-pharmacological analgesia.
Key Findings:
Mechanical stimuli can modulate neuroinflammation and spinal sensitization, with significant implications for pain management.
Tuina, as a form of controlled mechanical stimulation, shows potential for pain management.
There is a need for standardized mechanical dosing and mechanism-informed biomarkers to enhance clinical efficacy.
Interpretation:
Mechanical forces may serve as immunomodulatory cues that can reprogram neuroinflammation and reduce spinal sensitization, supporting non-pharmacological pain relief strategies through specific mechanisms.
Limitations:
Heterogeneity in dosing and outcomes across studies, which complicates the interpretation of results.
Inconsistencies in translational models used in research, affecting the applicability of findings.
Conclusion:
Future research should focus on developing quantifiable, personalized mechanotherapy protocols for chronic pain management, particularly in the areas of dosing standardization and biomarker identification.
With an aging population, spine disorders are becoming increasingly common. Age-related spinal degeneration is nearly universal, but not all patients experience symptoms—and not all degeneration progresses the same way.
