To determine the incidence of retinal detachment (RD) following acute retinal necrosis (ARN) and evaluate demographic and treatment-related associations using a large, multi-institutional database, including identification methods for RD and ARN.
Key Findings:
Overall incidence of RD was 12.49% (n=223) among 1,785 patients with ARN.
60.5% of RD cases occurred within the first 3 months post-diagnosis.
No significant differences in RD incidence based on age, sex, diabetes status, or immunosuppression, with treatment exposures viewed as proxies of disease severity.
Interpretation:
Treatment exposures should be interpreted as proxies of disease severity, not independent risk factors for RD.
Limitations:
Study limited to data from a single federated database, which may introduce biases.
Potential biases in treatment assignment and patient selection should be acknowledged.
Conclusion:
RD following ARN is most common within the first 3 months after diagnosis, highlighting the need for close monitoring during this period.
