Anxiety, depression and health-related quality of life in patients with thoracic aortic disease: a longitudinal study in a cardiothoracic outpatient clinic - Summary - MDSpire
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Anxiety, depression and health-related quality of life in patients with thoracic aortic disease: a longitudinal study in a cardiothoracic outpatient clinic
To describe longitudinal trajectories of HRQoL and psychological distress in patients with TAD and to examine associations with key demographic and clinical variables.
Approach:
Study Design: Retrospective analysis of 111 patients with 256 visits from 2023 to 2025, using linear mixed-effects models and logistic regression.
Key Findings:
Median EQ-5D-5L was 0.71 (IQR 0.55–0.88), EQ-VAS 70 (IQR 60–80), and PHQ-4 3 (IQR 1–5).
Time since surgery predicted HRQoL improvement (p < 0.001).
Preoperative patients had lower HRQoL and twice the odds of clinically relevant distress (OR 2.0, 95% CI 1.2–3.3).
Female sex showed nonsignificant trends toward lower HRQoL and higher distress.
Interpretation:
Preoperative TAD patients reported lower HRQoL and higher distress, while postoperative recovery was associated with gradual improvement.
Limitations:
The study reflects a real-world outpatient cohort with heterogeneous pre- and postoperative trajectories.
Pre- and postoperative classifications are based on clinical status at presentation rather than strict longitudinal follow-up.
Conclusion:
Findings reflect real-world patterns in a mixed pre-/postoperative outpatient cohort.
by Ismail Dalyanoglu, Anna Maria Markser, Johannes Nienhaus, Esma Yilmaz, Mohammed Morjan, Amin Thwairan, Ulrike Dinger, Artur Lichtenberg, Hannan Dalyanoglu
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