Enhancing targeted strategies for cancer immunotherapy by elucidating mRNA processing mechanisms
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By
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Xiao Lu
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Wenwen Gan
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Jiang Yuan
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Zhihao Chen
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May 25, 2026
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Objective:
To explore how mechanistic insights into mRNA processing can enhance the precision of cancer immunotherapy.
Key Findings:
- Aberrant splicing in tumors generates a significant number of neoantigens.
- Shared splice isoforms among patients could facilitate the development of mRNA vaccines.
- m6A modifications create an immunosuppressive network affecting immune checkpoint molecules.
- ADAR1-mediated RNA editing allows tumors to evade immune detection.
- Biomarkers based on splicing signatures may help in stratifying patients.
Interpretation:
Limitations:
- Challenges include off-target toxicity and intratumoral heterogeneity.
- Delivery technologies for mRNA-based therapies remain a hurdle.
Conclusion:
