Objective:

To examine the extent of skin photoaging in young Asian females (aged 18-35) and assess the impact of combined non-ablative bipolar radiofrequency and ablative fractional CO₂ laser treatments.

Key Findings:

• 71.29% of patients were classified as Grade I and 28.71% as Grade II in the Glogau classification.
• The combined cohort showed a significantly higher effective rate (95.08%) compared to the RF-alone cohort (78.75%; p < 0.001).
• Post-treatment symptom scores for pore size, hyperpigmentation, skin texture, and skin color were significantly lower in the combined cohort (all p < 0.05).
• GPS scores were significantly reduced in the combined cohort (1.58 ± 0.50 vs. 2.24 ± 0.56; p < 0.001).
• No significant difference in adverse reaction rates between cohorts (4.10% vs. 3.75%; p > 0.05).

Interpretation:

The combined treatment of non-ablative bipolar RF and ablative fractional CO₂ laser is more effective in alleviating photoaging symptoms in young Asian women, with no significant increase in adverse events.

Limitations:

• Retrospective design may introduce selection bias, potentially affecting the generalizability of the results.
• Limited generalizability due to the specific demographic of young Asian women.

Conclusion:

The combined method is a secure and efficient therapeutic approach for addressing early photoaging in young Asian females, primarily exhibiting mild to moderate photoaging, emphasizing the need for demographic-specific considerations.