A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study - Summary - MDSpire
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A higher monocyte-to-lymphocyte ratio is correlated with impaired glomerular function and adverse cardiac remodeling in elderly patients with atrial fibrillation: a retrospective study
To investigate the association between monocyte/lymphocyte ratio (MLR) and clinical biochemical indexes and cardiac remodeling in elderly patients with atrial fibrillation (AF).
Approach:
Study Design: A retrospective cross-sectional study involving 1,154 elderly Chinese patients (aged ≥ 65 years) with non-valvular AF was conducted.
Patient Grouping: Patients were categorized into low, moderate, and high MLR groups based on MLR tertiles.
Data Collection: Data were collected from medical records, including electrocardiographic examinations, echocardiography, and biochemical tests.
Key Findings:
High MLR (> 0.460) was independently associated with male sex.
High MLR was linked to decreased estimated glomerular filtration rate (eGFR).
High MLR correlated with lower plasma albumin levels.
High MLR was associated with cardiac ventricular dilatation and dysfunction.
Interpretation:
High MLR is linked to adverse cardiac remodeling and diminished glomerular function in elderly patients with AF.
Limitations:
The study is retrospective and conducted in a single medical center.
The findings may not be generalizable to all populations.
Conclusion:
High MLR was linked to male sex, decreased eGFR, lower plasma albumin level, and adverse cardiac remodeling in elderly patients with AF.
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