To evaluate the agreement, correlation, and diagnostic performance of a self-developed mobile application for bilirubin measurement compared with total serum bilirubin (TSB) and transcutaneous bilirubin (TcB) in screening neonatal hyperbilirubinemia.
Approach:
Key Findings:
Mobile app-derived bilirubin did not differ significantly from TSB (mean difference of −2.42 μmol/L).
Agreement was lower among preterm infants compared to term infants.
Mobile app-derived bilirubin was positively correlated with TSB (R2 = 0.776, P < 0.001).
The mobile application achieved an area under the curve of 0.936, sensitivity of 0.912, and specificity of 0.908.
TcB achieved an area under the curve of 0.937, sensitivity of 0.882, and specificity of 0.931.
Interpretation:
Mobile application-derived bilirubin showed good agreement with TSB and diagnostic performance comparable to TcB.
Limitations:
Study conducted in a single center, limiting generalizability.
Further technical optimization and multicenter validation are needed.
Conclusion:
The smartphone-assisted approach may serve as a supplementary tool for neonatal hyperbilirubinemia screening.
