Establishment of prognostic nomogram in cervical cancer with hepatitis B virus infection: a retrospective study - Summary - MDSpire

Establishment of prognostic nomogram in cervical cancer with hepatitis B virus infection: a retrospective study

  • By

  • Zhongyan Dou

  • Shuhui Yu

  • Jinping Zhang

  • Xingrao Wu

  • Kangming Li

  • Meiping Jiang

  • Chunfang Zhao

  • Lan Zhang

  • July 13, 2026

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Objective:

To identify prognostic factors and establish a nomogram for predicting overall survival in HBsAg-positive cervical cancer patients.

Approach:
  • Validation: Internal validation was conducted to assess the reliability of the nomogram using the bootstrap resampling method.
Key Findings:
  • The nomogram achieved a Harrell’s C-index of 0.817 (95% CI, 0.762–0.873), outperforming the FIGO staging system's C-index of 0.700 (95% CI, 0.637–0.764, P < 0.001).
Interpretation:

The study established a nomogram for preliminary prognostic evaluation of overall survival in HBsAg-positive cervical cancer patients, indicating its potential utility over the FIGO staging system.

Limitations:
  • The study is retrospective and may be subject to selection bias.
  • Further validation of the nomogram is required before clinical application.
Conclusion:

The nomogram provides a more accurate prognostic tool for HBsAg-positive cervical cancer patients, pending further validation.

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