To analyze the distribution of pathogens and their antimicrobial susceptibility patterns in patients with diabetic foot, specifically examining lipid parameters such as total cholesterol and triglycerides, and explore the association between these lipid levels and pathogen distribution as well as resistance patterns.
Key Findings:
Gram-positive bacteria predominated (54.12%), followed by gram-negative bacteria (38.82%).
Staphylococcus aureus and Pseudomonas aeruginosa were the most common isolates.
Gram-positive bacteria showed highest susceptibility to linezolid and vancomycin; gram-negative bacteria were most sensitive to amikacin and piperacillin-tazobactam.
No significant differences in lipid levels among different pathogen groups or between drug-resistant and non-resistant infections (all p > 0.05), indicating a lack of association.
Interpretation:
Lipid profiles were not significantly associated with pathogen distribution or antimicrobial resistance patterns in patients with diabetic foot infection, suggesting that lipid metabolism may not play a critical role in these aspects.
Limitations:
Retrospective nature of the study may limit the availability of complete data, such as prior antibiotic exposure, potentially affecting the reliability of the findings.
The study was conducted at a single center, which may affect the generalizability of the findings to broader populations.
Conclusion:
Further prospective studies are needed to clarify the role of lipid metabolism in infection susceptibility and clinical outcomes.
