Case Report: Pembrolizumab unmasks a capillary leak syndrome with chylothorax in early TNBC - Summary - MDSpire

Case Report: Pembrolizumab unmasks a capillary leak syndrome with chylothorax in early TNBC

  • By

  • Naïla Benkalfate

  • Ghazi Hadjamara

  • Caroline Petorin

  • Magaly Zappa

  • Aimable Habonimana

  • Dufens Pierre Louis

  • Anne-Laure Chene

  • Jean-Patrick Clarke

  • Renan Liberge

  • Kinane Drak Alsibai

  • Claire Defrance

  • Barbara Pistilli

  • Baptiste Boulet

  • Soraya Benguerfi

  • Houari Aissaoui

  • May 22, 2026

  • 0 min

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Objective:

To report a case of capillary leak syndrome (CLS) induced by pembrolizumab in a patient with early-stage triple-negative breast cancer (TNBC).

Key Findings:
  • Pembrolizumab can induce rare immune-related adverse events such as capillary leak syndrome.
  • The patient presented with symptoms consistent with CLS, including dyspnea and edema, after receiving pembrolizumab.
  • Corticosteroid therapy effectively resolved the symptoms and complications associated with CLS.
Interpretation:

Limitations:
  • The case is based on a single patient, limiting generalizability.
  • The diagnosis of CLS was established after ruling out other causes, which may not be feasible in all clinical settings.
Conclusion:

Original Source(s)

Case Report: Pembrolizumab unmasks a capillary leak syndrome with chylothorax in early TNBC

  • by Naïla Benkalfate, Ghazi Hadjamara, Caroline Petorin, Magaly Zappa, Aimable Habonimana, Dufens Pierre Louis, Anne-Laure Chene, Jean-Patrick Clarke, Renan Liberge, Kinane Drak Alsibai, Claire Defrance, Barbara Pistilli, Baptiste Boulet, Soraya Benguerfi, Houari Aissaoui

  • May 22, 2026

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