To systematically analyze the literature on cognitive dysfunction in type 2 diabetes mellitus (T2DM) and identify key research priorities and emerging trends in this area.
Key Findings:
1,752 publications were included, with a significant increase in annual publication volume post-2018, indicating growing interest in the field.
China, the USA, and the UK were the leading contributors to the research, highlighting geographical trends.
High-frequency keywords included 'type 2 diabetes mellitus', 'Alzheimer’s disease', and 'cognitive impairment', reflecting the focus areas.
Research focus has shifted towards neuroimaging, gut microbiota, and molecular mechanisms, suggesting evolving interests in underlying processes.
Interpretation:
Cognitive dysfunction in T2DM is a growing area of research with multidisciplinary characteristics, emphasizing the need for integrated studies to improve early screening and personalized treatment strategies.
Limitations:
The study primarily relied on publications from the Web of Science Core Collection, which may not capture all relevant research, potentially biasing the findings.
The analysis is limited to the data available until November 5, 2025, which may not reflect the most current research developments.
Conclusion:
Future research should enhance the integration of mechanism studies to advance understanding and treatment of cognitive dysfunction in T2DM, addressing the identified research priorities.
