Prevalence and Determinants of Diabetes Mellitus in 2338 Long-Term Dutch Childhood Cancer Survivors (DCCS-LATER2 Study) - Summary - MDSpire

Prevalence and Determinants of Diabetes Mellitus in 2338 Long-Term Dutch Childhood Cancer Survivors (DCCS-LATER2 Study)

  • By

  • Melissa Bolier

  • Demi T C de Winter

  • Marta Fiocco

  • Sjoerd A A van den Berg

  • Dorine Bresters

  • Eline van Dulmen-den Broeder

  • Margriet van der Heiden-van der Loo

  • Imo Hoefer

  • Geert O Janssens

  • Leontien C M Kremer

  • Jacqueline J Loonen

  • Marloes Louwerens

  • Heleen J van der Pal

  • Saskia M F Pluijm

  • Wim J E Tissing

  • Hanneke M van Santen

  • Andrica C H de Vries

  • Aart-Jan van der Lely

  • Marry M van den Heuvel-Eibrink

  • Sebastian J C M M Neggers

  • February 7, 2025

  • 0 min

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Objective:

To assess the prevalence and determinants of diabetes mellitus (DM) in a nationwide cohort of childhood cancer survivors (CCS).

Key Findings:
  • Increased odds for hyperglycemia (aOR = 2.72), previous DM diagnosis (aOR = 3.03), and antidiabetic medication use (aOR = 2.94) in CCS compared to the reference cohort.
  • Significant determinants of DM include age, BMI, family history of DM, prior abdominal/pelvic radiotherapy, total body irradiation, hypogonadism, hypertension, and dyslipidemia.
  • A statistically significant interaction between age and sex on DM development was identified.
Interpretation:

CCS exhibit a three-fold increased risk of DM, highlighting the need for early risk-based screening and lifestyle interventions.

Limitations:
  • Potential underestimation of DM prevalence due to reliance on self-reported data.
  • Study population limited to survivors treated in Dutch pediatric oncology centers.
Conclusion:

The study underscores the importance of identifying modifiable risk factors for DM in CCS to improve long-term health outcomes.

Original Source(s)

Prevalence and Determinants of Diabetes Mellitus in 2338 Long-Term Dutch Childhood Cancer Survivors (DCCS-LATER2 Study)

  • by Melissa Bolier, Demi T C de Winter, Marta Fiocco, Sjoerd A A van den Berg, Dorine Bresters, Eline van Dulmen-den Broeder, Margriet van der Heiden-van der Loo, Imo Hoefer, Geert O Janssens, Leontien C M Kremer, Jacqueline J Loonen, Marloes Louwerens, Heleen J van der Pal, Saskia M F Pluijm, Wim J E Tissing, Hanneke M van Santen, Andrica C H de Vries, Aart-Jan van der Lely, Marry M van den Heuvel-Eibrink, Sebastian J C M M Neggers

  • February 7, 2025

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