To summarize the correlation between skin barrier dysfunction and psoriasis, elucidate their interaction mechanisms, and analyze the clinical value of skin barrier repair.
Approach:
Review Methodology: Systematic searches in PubMed, Web of Science, Embase, and CNKI databases were conducted to identify relevant studies on skin barrier dysfunction in psoriasis, focusing on various structural and functional components.
Key Findings:
Skin barrier dysfunction is an early and pivotal pathogenic driver of psoriasis.
Mechanisms of barrier impairment include keratinocyte hyperproliferation, abnormal expression of structural proteins, tight junction disruption, aquaporin 3 dysfunction, and dysregulated lipid metabolism.
The skin barrier's structural integrity is crucial for maintaining homeostasis and preventing disease progression.
Interpretation:
Limitations:
Significant gaps in understanding the core molecular mechanisms of interaction.
Inconsistencies in findings related to key barrier-related molecules in psoriatic lesions.
Lack of standardized clinical application for skin barrier repair.
Recognizing sustained switches between the two diseases can prevent premature discontinuation of effective biologics and point toward Janus kinase inhibitors, a 148-patient cohort suggests.
