To conduct a retrospective descriptive analysis of the clinical manifestations, pathological characteristics, diagnostic approaches, and treatment outcomes of Castleman disease (CD) in a Chinese regional population, thereby contributing real-world evidence to improve clinical management of this rare disorder.
Approach:
Classification: 7 patients diagnosed with unicentric CD (UCD; 5 hyaline vascular type, 2 mixed type) and 5 with multicentric CD (MCD; 4 plasma cell type, 1 mixed type) based on Frizzera classification.
Key Findings:
All 12 patients were alive at follow-up.
UCD patients treated with complete surgical resection had no recurrence.
MCD mixed-type patient achieved complete remission after switching to oral TCD regimen.
MCD patients treated with primary R-CHOP had favorable outcomes with no recurrence.
Interpretation:
Castleman disease was associated with a favorable short-term prognosis following individualized treatment.
Limitations:
Small sample size limits generalizability and may affect the reliability of the findings.
Single-center study may not represent broader populations.
Conclusion:
Complete surgical resection is curative for resectable UCD, while MCD typically requires systemic therapy. R-CHOP is an effective first-line alternative for idiopathic multicentric Castleman disease in resource-limited settings.
