Maternal TSH and FT4 changes during pregnancy as risk factors for preeclampsia in euthyroid women
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By
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Jianxia Lin
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Yili Zhang
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Yu Meng
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Yan Su
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Mengfan Song
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May 26, 2026
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Objective:
To investigate the associations between FT4/TSH changes during pregnancy and the risk of preeclampsia among women with normal thyroid function.
Key Findings:
- TSH changes showed a J-shaped nonlinear association with preeclampsia risk, with a threshold of 0.68 mIU/L.
- FT4 changes were linearly and negatively associated with preeclampsia risk.
- The Complete Decompensation group (ΔTSH > 0.68, ΔFT4 ≤ -3.30) had the highest risk of preeclampsia (2.7%, aOR = 1.89, P < 0.001).
- Preeclampsia-related complications included preterm birth (20.3%, aOR = 3.35, P = 0.016) and low birth weight (18.9%, aOR = 2.46, P = 0.046).
- 21.6% of preeclampsia cases and 36.6% of severe cases were attributable to the Complete Decompensation pattern.
Interpretation:
Remove or rephrase to eliminate unsupported claims.
Limitations:
- Retrospective design may limit causal inferences.
- Study population limited to a single tertiary hospital, which may affect generalizability.
Conclusion:
Revise to focus solely on findings without implications.
